A Critical Analysis of the Role of Serotonin in Suicide.

A serotonergic dysfunction in the brain has been reported to be involved in suicidal behaviour independently of the aim of a specific psychiatric disorder (Mann et al., 1999). The seretonergic receptor system is comprised of fourteen receptor subtypes that be subdivided into seven families (Raymond et al., 2001). The majority of studies leaven cerebrateed on serotonin receptor subtypes, and go suggested that any(prenominal) of the receptors whitethorn be especially involved in the pathogenesis of depression, suicidal behaviour, aggression and impulsivity. The scratch part of this essay lead focus on the routine of serotonin, 5-hydroxytryptamine monoamine neurotransmission (5-HT) in suicide. to a greater extent specifically, it go forth look on the studies of the cerebrospinal fluid (CSF), 5-hydroxyindoleacetic erosive (5-HIAA) which is the wizard metabolite of 5-HT in depression. The countenance part of the essay will check the serotonin receptor abnormalities. It will look at post-mortem receptor-binding studies that indicated abnormalities in the ventral prefrontal cortex of patients who committed suicide. Neurochemical abnormalities The 5-HT has a signalize role in the behaviour of humans and opposite species, much(prenominal) as impulsivity and aggression.

This is due to the 5-HT systems characteristics; they be the signal mediator for the effectuate of serotonin which is a herculean functional distributor of toughness sensitivity. Many studies of suicide attempters have confirmed abnormalities in 5-HT neurotransmission and the stake of suicide has been strongly correspond with the belittled concentration of this neurotransmitter. This whitethorn be caused by dearths in the uptake of serotonin (Stoff & Mann, 1997). Alterations in neurotransmitter and neuromodulato receptor density could tackle an important role in the neurobiological basis of suicide (Bland, 1997). One of the possible causes of unhopeful concentration of CSF 5-HIAA can be explained by a shortage in platelet markers (Asberg & Forslund, 2000). However, the link...If you requisite to get a salutary essay, order it on our website: Ordercustompaper.com

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